Comprehensive Landscape of the Tumor Microenvironment Analyzed with CyTOF | Hiroyoshi Nishikawa, PhD

Hiroyoshi Nishikawa, MD, PhD discusses Imaging Mass Cytometry in the presentation Comprehensive Landscape of the Tumor Microenvironment Analyzed with CyTOF Technology. Immune escape mechanisms such as the induction or recruitment of immunosuppressive cells and the increased expression of various immunosuppressive molecules including PD-1/PD-1 ligands are essential processes during cancer development and progression, leading to the development of complex immune-suppressive networks in the tumor microenvironment. Thus, high-dimensional immune profiling using CyTOF® technology for single-cell phenotype and function analysis plays an important role in developing more effective cancer immunotherapeutic strategies and in defining biomarkers for stratifying responders and nonresponders via the detailed analysis of immune responses in cancer patients.


In this presentation from the July 2020 Fluidigm Oncology and Infectious Disease Virtual Summit, Nishikawa outlines the current status of cancer immunotherapy and recent advances in the field. He also describes:

- The importance of biomarkers in the cancer immunotherapy field and in PD-1 blockade therapy
- His work in assessing a strong suppressive tumor microenvironment in EGFR-mutated non-small cell lung carcinoma (NSCLC) tumors
- How Imaging Mass Cytometry™ is used to understand the localization of tumor antigen-specific T cells


Hiroyoshi Nishikawa, MD, PhD
Division Chief of Cancer Immunology
Research Institute/Exploratory Oncology Research & Clinical Trial Center (EPOC)
National Cancer Center, Tokyo/Chiba, Japan

Professor of Immunology
Nagoya University Graduate School of Medicine